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. 2014 Nov 7;5(23):12141–12150. doi: 10.18632/oncotarget.2559

Figure 1. Several MICB targeting miRNAs are predicted to target TWIST1.

Figure 1

Schematic representation of MICB 3′UTR including the location of the various MICB targeting miRNAs. (B) Schematic representation of TWIST1 3′UTR that includes the location of predicted targeting miRNAs. (C) Control 3′UTR, or TWIST1 3′UTR were fused to firefly luciferase, and co-transfected with renilla luciferase into DU 145 cells over expressing the microRNAs indicated at the X axis. miR-17-5p and miR-20a, and miR-93 and miR-106b were co-expressed. The luciferase activity was measured and normalized to renilla activity. The control 3′UTR activity was set to 1. Results are representative of two independent experiments. *P < 0.035.