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. 2014 Oct 28;5(23):12371–12382. doi: 10.18632/oncotarget.2642

Figure 6. Growth suppressive effect of MELK inhibitor OTS167 in AML primary blasts.

Figure 6

(A) MTT assay performed in blasts from four AML patients after 48-hour incubation with OTS167 at indicated doses. (B) Apoptosis assessed by Annexin and PI staining in primary blasts treated with 50nM of OTS167 for 72 hours (the numbers represent the percentage of cells in each quarter). (C) Myeloid differentiation assessed by CD11b staining in primary blasts treated with 50nM of OTS167 for 4 days. (D) Cell pellets of primary blasts treated with 25, 50, or 100nM of OTS167 for 4 days (an arrow points to the cell pellet). (E) Colony assay were performed in bone marrow blasts (BM) treated with 25nM OTS167 for 24 hours before plating; error bars represent standard error (SE).