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Correlation between MELK and FOXM1 (A), CCNB1 (B), BIRC5 (C) and CDC25B (D) mRNA expression in adult AML patients. (E) FOXM1 expression measured by western blot in MV4-11, THP-1, U937 and KG1 cells treated with 50 or 100nM of OTS514 for 12 hours, (F) mRNA expression of CDC25B and CCNB1 in MV4-11 and KG1 cells treated with OTS167 measured by qRT-PCR and normalized to ABL or B2M respectively.
