Table 2.
Echocardiographic parameters and right heart catheterization
| Echocardiography | ILD without RVSD n = 58 | ILD with RVSD n = 18 | * P - value |
|---|---|---|---|
| TAPSE, mm | 20.4 ± 3.5 | 19.7 ± 2.9 | 0.64 |
| RVSP, mmHg | 31.9 (18.9-44.9) | 31.9 (24.4-39.4) | 0.64 |
| RVFAC, % | 39.4 ± 9.1 | 37.7 ± 10.4 | 0.49 |
| LVEF, % | 63.6 ± 8.4 | 65.6 ± 5.8 | 0.54 |
| LVDd, mm | 41.6 (38.6-44.6) | 42.5 (38.5-46.5) | 0.086 |
| Right heart catheterization | ILD without RVSD n = 16 | ILD with RVSD n = 39 | *P - value |
| RAP, mmHg | 4.5 ± 3.4 | 6.2 ± 4.1 | 0.94 |
| mPAP, mmHg | 19.0 (15.5-22.5) | 21.5 (17.0-26.0) | 0.005 |
| PCWP, mmHg | 8.2 ± 3.7 | 8.5 ± 3.8 | 0.21 |
| SVR, dyne·sec·cm-5 | 324 (210-438) | 315 (223-407) | 0.41 |
| PVR, dyne·sec·cm-5 | 152 (85-219) | 147 (36-258) | 0.060 |
| Cardiac Index, L/min/m2 | 2.8 (2.3-3.3) | 2.8 (2.3-3.3) | 0.95 |
Values are presented as mean ± standard deviation (SD) or median (1st quartile and 3rd quartile).
RV dysfunction was defined as RVEF ≤45% evaluated by cine CMR.
*P value represents significance of difference between ILD patient with RVSD and those without.
ILD: interstitial lung disease; LVDd: left ventricular dimension at end of diastole; LVEF: left ventricular ejection fraction; mPAP: mean pulmonary arterial pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; RAP: right atrial pressure; RVFAC: right ventricular fractional area change; RVSD: right ventricular systolic dysfunction; RVSP: right ventricular systolic pressure; SVR: systemic vascular resistance; TAPSE: tricuspid annular plane systolic excursion.