Table 3.
Cox Proportional Hazards Analysis for Future Events in Patients with ILD
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Patients’ characteristics | ||||||
| Age, year | 0.987 | 0.932 – 1.046 | 0.66 | 0.978 | 0.913 – 1.048 | 0.53 |
| Male, yes | 1.382 | 0.298 – 6.401 | 0.68 | 1.015 | 0.190 – 5.420 | 0.99 |
| MRC dyspnea scale | 1.660 | 0.938 – 2.937 | 0.082 | Not selected | ||
| BMI, kg/m2 | 1.021 | 0.859 – 1.213 | 0.82 | Not selected | ||
| Systolic BP, mmHg | 1.018 | 0.981 – 1.056 | 0.35 | Not selected | ||
| Diastolic BP, mmHg | 1.021 | 0.970 – 1.074 | 0.43 | Not selected | ||
| Heart rate, bpm | 1.011 | 0.978 – 1.046 | 0.51 | Not selected | ||
| Blood testing | ||||||
| BNP, pg/ml | 1.000 | 0.997 – 1.002 | 0.88 | Not selected | ||
| Creatinine, mg/dl | 4.179 | 0.505 – 34.60 | 0.19 | Not selected | ||
| KL-6, U/ml | 1.000 | 0.999 – 1.001 | 0.40 | Not selected | ||
| LDH, IU/l | 1.003 | 0.991 – 1.015 | 0.63 | Not selected | ||
| CRP, mg/dl | 0.827 | 0.430 – 1.591 | 0.57 | Not selected | ||
| Pulmonary function test | ||||||
| FVC, % predicted | 0.996 | 0.967 – 1.025 | 0.77 | Not selected | ||
| FEV1, % predicted | 0.958 | 0.915 – 1.003 | 0.065 | Not selected | ||
| DLCO, % predicted | 0.965 | 0.930 – 1.002 | 0.064 | Not selected | ||
| 6 min walk distance, m | 0.995 | 0.985 – 1.005 | 0.35 | Not selected | ||
| Right heart catheterization | ||||||
| mPAP, mmHg | 1.003 | 0.956 – 1.051 | 0.913 | Not selected | ||
| PCWP, mmHg | 1.001 | 0.843 – 1.189 | 0.992 | Not selected | ||
| Echocardiography | ||||||
| TAPSE, mm | 0.863 | 0.727 – 1.024 | 0.092 | Not selected | ||
| RVFAC, % | 0.916 | 0.853 – 0.985 | 0.018 | 0.938 | 0.873 – 1.007 | 0.078 |
| Cine CMR parameters | ||||||
| CMR derived RVEF, % | 0.889 | 0.809 – 0.976 | 0.014 | 0.897 | 0.810 – 0.992 | 0.035 |
BMI: body mass index; BNP: brain natriuretic peptide; BP: blood pressure; CRP: C-reactive protein; CMR: cardiovascular magnetic resonance; DLCO: diffusing capacity of the lungs for carbon monoxide, FEV: forced expiratory volume; FVC: forced vital capacity; ILD: interstitial lung disease; LDH: lactic acid dehydrogenase; MRC: Medical Research Council; mPAP: mean pulmonary arterial pressure; PCWP: pulmonary capillary wedge pressure; RVEF: right ventricular ejection fraction; RVFAC: right ventricular fractional area change; TAPSE: tricuspid annular plane systolic excursion.