Table 1.
Antineoplastic effects of H-1PV on different human tumor entities
| Tumor entity | In vitro system | In vitro effect | In vivo system | In vitro effect | References |
|---|---|---|---|---|---|
| Glioblastoma and gliosarcoma | Cell lines and primary cells | Dose-dependent killing at low MOIs | Immunocompetent Wistar rats; Nude rats | Complete tumor regression and increased animal survival | [77,79] |
| Neuroblastoma | Cell lines | Highly efficient cell killing | N.D. | N.D. | [48] |
| Medulloblastoma | Cell lines | 40-100% cell lysis | N.D. | N.D. | [84] |
| Burkitt’s lymphoma | EBV positive and negative cell lines | 80-100% cell death | SCID mice | Tumor regression and significant prolongation of animal survival | [85] |
| Breast | Cell lines and primary cells | 20-80% cell death | Nude mice | Inhibition of tumor formation; tumor regression | [86,88,89] |
| Pancreatic carcinoma | Cell lines and short-term cultures | 20-100% cell killing | SCID mice; Nude rats | Tumor regression | [13,91] |
| Cervical carcinoma | Cell lines | 40-100% cell lysis | SCID mice; Nude rats | Tumor regression | [13,96] |
| Gastric tumors | Cell lines | 20-80% cell death | Nude mice | Inhibition of tumor formation | [98] |
| Melanoma | Cell lines | Cell killing | N.D. | N.D. | [64] |
| Hepatoma | Cell lines | 80% reduction of metabolic activity | Nude mice | Inhibition of tumor formation | [99] |
| Colon | Cell lines | Limited virus replication and cytotoxicity | N.D. | N.D. | [66,102] |
N.D. Not determined; EBV, Epstein-Barr virus.