Table 2.
Proportions of the four molecular subgroups reported in the present study, other Mexican studies, and studies from other countries.
| Author, year of publication [Reference] | Country | Number of patients |
ETV6-RUNX1
n(%) |
TCF3-PBX1
n (%) |
MLL rearrangements n (%) |
BCR-ABL1
n (%) |
|---|---|---|---|---|---|---|
| MIGICCL study, 2014 [present study] | Mexico City | 287 | 24 (7.4) | 20 (7.1) | 4 (1.4) | 5 (1.8) |
| Other Mexican studies | ||||||
| Pérez-Vera et al., 2008 [4] | Mexico City | 59 | 5 (8.7) | — | 5 (8.7) | 1 (1.7) |
| Jiménez-Morales et al., 2008 [5] | Mexico City | 53 | 7 (13.5) | 6 (11.5) | — | 2 (3.8) |
| Daniel-Cravioto et al., 2009 [6] | Mexico City | 26 | 1 (3.8) | — | 17 (65.4) | 1 (3.8) |
| Studies from other countries | ||||||
| Amor et al., 1998 [11] | Australia | 66 | 22 (33.0) | — | — | — |
| Zuna et al., 1999 [12] | Czech Republic | 190 | 41 (21.6) | — | — | — |
| Codrington et al., 2000 [13] | England | 56 | 22 (39.0) | — | — | — |
| Siraj et al., 2003 [14] | India | 259 | 18 (7.0) | 18 (7.0) | 2 (4)∗ | 14 (5.0) |
| Mesquita et al., 2003 [15] | Brazil | 88 | 10 (11.4) | 5 (5.7) | 1 (1.1) | 1 (1.1) |
| Pui et al., 2003 [16] | ||||||
| White children | USA | 338 | 64 (18.9) | 10 (3.0) | 10 (3.0) | 8 (2.4) |
| Black children | USA | 68 | 9 (13.2) | 8 (11.8) | 1 (1.5) | 4 (5.9) |
| Aldrich et al., 2006 [17] | ||||||
| Non-Hispanic White | USA | 140 | 34 (24.3) | 6 (4.3) | 4 (2.9) | 1 (0.7) |
| Hispanic | USA | 151 | 19 (12.6) | 7 (4.6) | 3 (2.0) | 2 (1.3) |
| Lazic et al., 2010 [18] | Serbia | 70 | 12 (17.1) | 6 (8.6) | 0 | 7 (10.0) |
| Alonso et al., 2012 [19] | Argentina | 380 | 49 (12.9) | 19 (5.0) | 40 (10.5) | 6 (1.6) |
MIGICCL: Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
— Not screened.
∗Other MLL rearrangements were detected in two (4%) of 50 samples analyzed by Southern blot.