Table 1.
5-HT2A receptor binding in wildtype and tph2KI mice. Densiometric measurements were performed on autoradiograms from sections incubated with 3H-MDL100907 in different brain regions. The data are expressed as binding in areas of interest and the relative change and statistical difference as revealed by Student t-tests are indicated. Significant changes are present in the prefrontal cortex, the striatum, and the substantia nigra.
| Wildtype (fmol/mg) |
n | Tph2KI (fmol/mg) |
n | % change | P-value | |
|---|---|---|---|---|---|---|
| Prefrontal cortex | 48.40 ± 1.16 | 7 | 53.24 ± 1.07 | 8 | 10.00 | 0.0088 ** |
| Frontal cortex | 39.54 ± 1.34 | 10 | 42.38 ± 1.33 | 8 | 7.18 | 0.1271 |
| Striatum | 20.54 ± 1.09 | 10 | 25.86 ± 1.21 | 8 | 25.90 | 0.0048 ** |
| Parietal cortex | 30.67 ± 1.38 | 6 | 33.45 ± 1.38 | 8 | 9.06 | 0.1898 |
| Hippocampus | 15.09 ± 0.75 | 7 | 14.25 ± 0.69 | 7 | −5.57 | 0.4202 |
| Hypothalamus | 12.55 ± 0.49 | 6 | 15.06 ± 1.10 | 7 | 20.00 | 0.0734 |
| Substantia nigra | 6.24 ± 0.34 | 8 | 7.52 ± 0.39 | 8 | 20.51 | 0.0271* |
| Brainstem | 7.48 ± 0.34 | 9 | 8.30 ± 0.40 | 8 | 10.96 | 0.1323 |
| Cerebellum | 2.66 ± 0.32 | 9 | 2.88 ± 0.30 | 7 | 8.27 | 0.6296 |