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. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: J Bone Miner Res. 2014 Sep;29(9):1970–1980. doi: 10.1002/jbmr.2223

Figure 1. β3 Positive Vessels are Present in New Woven Bone Following WBF Loading.

Figure 1

Following damaging mechanical loading, immunohistochemistry revealed that β3 integrin was expressed on few vessels on A) day 1 and B) day 3. The strongest expression of β3 integrin occurs in neovasculature on C) day 7, though expression persists at D) day 14. Muscle (M), pre-existing cortical bone (CB), and new woven bone (WB) are labeled in each cross section, and the double sided arrow labels the expanded periosteal region (days 1 and 3) that becomes woven bone (days 7 and 14).