Skip to main content
. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: J Bone Miner Res. 2014 Sep;29(9):1970–1980. doi: 10.1002/jbmr.2223

Figure 4. Increase in Vasculature following Mechanical Loading Is Blunted by Nanoparticle Treatment.

Figure 4

A) Blood vessels (black arrows) were quantified using immunohistochemistry against von Willebrand Factor (vWF). Muscle (M), pre-existing cortical bone (CB), and new woven bone (WB) are labeled, and the double-sided arrow is the expanded periosteal region. B) Significant increases in WBF loaded limbs were evident at all time points with treatment-related effects at days 7 and 14 after loading. C) Small but significant increases in vascularity in LBF loaded limbs were inhibited using anti-angiogenic nanoparticles at days 7 and 14. * p < 0.05 vs. Non-Loaded. + p < 0.05 vs. Vehicle.