Table 1.

Mechanical testing of stress fracture repair following WBF loading and treatment with α_vβ₃ integrin targeted nanoparticles or vehicle at 7 and 14 days. In the Day 14 Nanoparticles (7 days) group, animals were sacrificed at day 14, but only received nanoparticles for the first 7 days.

Group	Forelimb	Ultimate Force (N)	Stiffness (N/mm)	Displ. to Failure (mm)	Pre-Yield Displ. (mm)	Post-Yield Displ. (mm)	Energy to Failure (J)	Pre-Yield Energy (J)	Post-Yield Energy (J)	IDI (mm)	TID (mm)
Day 7 Vehicle	Loaded	23.3 ± 2.4*	8.9 ± 0.6*	5.2 ± 1.0	3.5 ± 0.3	1.7 ± 0.8	72.5 ± 16.0	39.6 ± 4.4	32.9 ± 15.9	15.2 ± 1.8*	131.0 ± 18.8*
	Non-Loaded	26.5 ± 1.4	11.6 ± 1.0	4.9 ± 0.5	3.4 ± 0.4	1.3 ± 0.4	72.8 ± 9.4	39.6 ± 2.8	31.8 ± 9.2	9.1 ± 0.9	58.3 ± 4.3
Day 7 Nanoparticles	Loaded	22.7 ± 1.0*	8.3 ± 0.4*	4.8 ± 0.3	3.5 ± 0.3	1.3 ± 0.3*	67.0 ± 5.4*	40.0 ± 2.5	27.0 ± 6.1*	18.2 ± 2.9*	156.6 ± 20.8*
	Non-Loaded	25.6 ± 1.6	11.3 ± 0.5	5.0 ± 0.3	3.2 ± 0.3	1.8 ± 0.3	79.9 ± 5.3	39.7 ± 3.6	40.2 ± 4.6	10.8 ± 1.0	65.8 ± 6.4
Day 14 Vehicle	Loaded	25.5 ± 2.2	10.7 ± 0.8	5.8 ± 0.4*	3.3 ± 0.1*	2.5 ± 0.5*	98.2 ± 8.8*	44.5 ± 4.1*	53.7 ± 7.9*	11.8 ± 1.6*	87.6 ± 8.5*
	Non-Loaded	23.7 ± 2.4	11.2 ± 0.6	4.6 ± 0.8	2.9 ± 0.2	1.7 ± 0.9	69.0 ± 11.8	34.1 ± 3.4	34.9 ± 12.1	8.4 ± 0.8	60.4 ± 13.9
Day 14 Nanoparticles (7 days)	Loaded	24.0 ± 1.2	11.5 ± 0.6*	4.7 ± 0.8	3.0 ± 0.2*	1.7 ± 0.7	75.6 ± 15.4	39.9 ± 3.3*	35.7 ± 14.4	12.5 ± 1.0*	97.4 ± 12.8*
	Non-Loaded	23.7 ± 1.8	12.9 ± 1.2	4.3 ± 0.8	2.4 ± 0.2	1.9 ± 0.7	67.9 ± 12.6	30.9 ± 2.4	37.0 ± 12.6	7.5 ± 2.0	56.6 ± 5.8
Day 14 Nanoparticles (14 days)	Loaded	24.9 ± 1.1	13.4 ± 2.3	4.1 ± 0.9	2.8 ± 0.4*	1.4 ± 0.6	70.7 ± 14.8	39.4 ± 4.0*	31.3 ± 13.7	12.1 ± 1.6*	94.7 ± 11.6*
	Non-Loaded	24.3 ± 1.9	14.6 ± 3.2	4.2 ± 0.6	2.3 ± 0.4	1.9 ± 0.6	68.5 ± 10.5	29.5 ± 2.9	39.0 ± 10.9	7.7 ± 2.0	53.6 ± 9.1

^*p < 0.05.