Table 1. Details of Risk Loci from Meta-Analysis Used to Calculate Total Genetic Risk Score.
| Marker | Chr | Position | Gene | Overall | Amish | Unrelated | Weights |
|---|---|---|---|---|---|---|---|
| OR | MAF | MAF | |||||
| rs6656401 | 1 | 207692049 | CR1 | 1.18 | 0.24 | 0.18 | 0.052 |
| rs6733839 | 2 | 127892810 | BIN1 | 1.22 | 0.45 | 0.4 | 0.062 |
| rs35349669 | 2 | 234068476 | INPP5D | 1.08 | 0.45 | 0.5 | 0.024 |
| rs190982 | 5 | 88223420 | MEF2C | 0.93 | - | - | - |
| rs9271192 | 6 | 32578530 | HLA-DRB5/ | 1.11 | 0.18 | 0.28 | 0.033 |
| HLA-DRB1 | |||||||
| rs10948363 | 6 | 47487762 | CD2AP | 1.1 | - | - | - |
| rs2718058 | 7 | 37841534 | NME8 | 0.93 | 0.29 | 0.35 | 0.023 |
| rs1476679 | 7 | 100004446 | ZCWPW1 | 0.91 | 0.28 | 0.29 | 0.03 |
| rs11771145 | 7 | 143110762 | EPHA1 | 0.9 | 0.27 | 0.32 | 0.033 |
| rs28834970 | 8 | 27195121 | PTK2B | 1.1 | 0.32 | 0.35 | 0.03 |
| rs9331896 | 8 | 27467686 | CLU | 0.86 | 0.36 | 0.41 | 0.047 |
| rs10838725 | 11 | 47557871 | CELF1 | 1.08 | 0.35 | 0.31 | 0.024 |
| rs983392 | 11 | 59923508 | MS4A6A | 0.9 | - | - | - |
| rs10792832 | 11 | 85867875 | PICALM | 0.87 | 0.45 | 0.35 | 0.044 |
| rs11218343 | 11 | 121435587 | SORL1 | 0.77 | 0.05 | 0.04 | 0.082 |
| rs17125944 | 14 | 53400629 | FERMT2 | 1.14 | 0.05 | 0.11 | 0.041 |
| rs10498633 | 14 | 92926952 | SLC24A4/RIN3 | 0.91 | 0.2 | 0.22 | 0.03 |
| rs8093731 | 18 | 29088958 | DSG2 | 0.73 | 0.01 | 0.01 | 0.099 |
| rs4147929 | 19 | 1063443 | ABCA7 | 1.15 | - | - | - |
| rs3865444 | 19 | 51727962 | CD33 | 0.94 | 0.29 | 0.3 | 0.019 |
| rs7274581 | 20 | 55018260 | CASS4 | 0.88 | 0.1 | 0.08 | 0.04 |
| APOE E4 | 19 | 19q13.2 | APOE | 2.5 | 0.14 | 0.26 | 0.287 |
Alleles, MAF, and overall OR are published values. Chr = chromosome. Pos = position in bp. MAF = minor allele frequency. OR = odds ratio. Adapted from Lambert, et al, 2013 [16]. Allele frequency was calculated using the 921 Amish samples and the 971 samples from the unrelated dataset that passed QC in the follow-up genotyping phase.