Table 8. MQLS-corrected allele frequencies and case-control association p-values for the top sequencing variants in the sequencing dataset.
| Marker | Chr | Position | Case | Control | Overall | p value | Gene | Function |
|---|---|---|---|---|---|---|---|---|
| MAF | MAF | MAF | ||||||
| rs41291476 | 10 | 102762544 | 0.0104 | 0.0019 | 0.0013 | 1.25E-06 | LZTS2 | synonymous |
| rs147224053 | 15 | 91503598 | 0.0104 | 0.0019 | 0.0013 | 1.25E-06 | RCCD1 | synonymous |
| rs4548 | 3 | 128525253 | 0.0987 | 0.0259 | 0.0525 | 3.31E-06 | RAB7A | synonymous |
| rs11380 | 12 | 6601475 | 0.0156 | 0.0078 | 0.0072 | 4.68E-06 | MRPL51 | missense |
| rs201285308 | 5 | 176008380 | 0.0156 | 0.0078 | 0.0072 | 5.00E-06 | CDHR2 | missense |
| rs41279402 | 20 | 3785672 | 0.0414 | 0.0036 | 0.0108 | 9.28E-06 | CDC25B | UTR-3 |
| 6_137234733 | 6 | 137234733 | 0.0403 | 0.0171 | 0.0199 | 1.01E-05 | PEX7 | UTR-3 |
| rs11676272 | 2 | 25141538 | 0.5938 | 0.4151 | 0.4619 | 1.28E-05 | ADCY3 | missense |
| rs144407106 | 6 | 136710582 | 0.0511 | 0.0203 | 0.0277 | 1.53E-05 | MAP7 | synonymous |
| rs149872991 | 15 | 91496233 | 0.0278 | 0.005 | 0.0085 | 3.74E-05 | UNC45A | missense |
| rs147643564 | 4 | 175158508 | 0.0651 | 0.0195 | 0.0318 | 4.67E-05 | FBXO8 | UTR-3 |
| rs146399677 | 20 | 3785297 | 0.041 | 0.0076 | 0.0129 | 4.89E-05 | CDC25B | synonymous |
| rs56400929 | 10 | 105762909 | 0.0104 | 0 | 0.001 | 7.00E-05 | SLK | missense |
| rs150358287 | 20 | 3687141 | 0.0894 | 0.0374 | 0.0455 | 7.94E-05 | SIGLEC1 | stop-gained |
| rs34270879 | 10 | 90673047 | 0 | 0.0434 | 0.0352 | 9.17E-05 | STAMBPL1 | missense |
Chr = chromosome. MAF = minor allele frequency. Nucleotide position is based upon the UCSC hg19 human reference genome. Gene and Function annotated by SeattleSeq134.