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. 2015 Feb 10;9(2):e0003464. doi: 10.1371/journal.pntd.0003464

Figure 6. The outburst of systemic inflammatory cytokines is highly dependent on TLR4 signaling and increased by parasite infection.

Figure 6

The cytokine production was quantified by ELISA in plasma collected from all groups of mice at 24 weeks of treatment with LFD, MFD, I+LFD or I+MFD. (A) WT CCL2: **p < 0.01 MFD vs. LFD and *p < 0.05 I+LFD vs. LFD; IL6: *p < 0.05 MFD vs. LFD, **p < 0.01 I+LFD vs. LFD, ***p < 0.001 MFD vs. I+MFD and **p < 0.01 I+LFD vs. I+MFD; IFNγ: *p < 0.05 MFD vs. LFD, **p < 0.01 I+LFD vs. LFD, **p < 0.01 MFD vs. I+MFD and *p < 0.05 I+LFD vs. I+MFD; IL17: **p < 0.01 MFD vs. LFD, **p < 0.01 I+LFD vs. LFD, ***p < 0.001 MFD vs. I+MFD and *p < 0.05 I+LFD vs. I+MFD. (B) TLR4-/- CCL2: *p < 0.05 I+LFD vs. LFD; IFNγ: *p < 0.05 MFD vs. I+MFD; IL17: **p < 0.01 I+LFD vs. LFD and ***p < 0.001 MFD vs. I+MFD. All data are shown as mean ± SEM of four to eight mice per group from one experiment representative of two performed. A p-value <0.05 was considered significant using Two-way ANOVA test.