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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Mol Cell Cardiol. 2014 Nov 6;79:32–41. doi: 10.1016/j.yjmcc.2014.10.018

Figure 2. Effects of HF remodeling on Ca transient, SR load, and fractional SR Ca release.

Figure 2

Shown are whole-cell SR Ca, cytosolic free Ca, and a line scan of the cytosolic free Ca. SR load and cytosolic Ca peak time are marked. A. Normal control. B. RyR, SERCA and NCX remodeled without TT disruption. C. RyR, SERCA and NCX remodeled with TT disruption (pLCC=30%). PCL=500 ms and [Na]i=9 mM. D. Effects of remodeling and TT disruption on fractional SR Ca release curves under the same conditions as in A–C. The fractional release curves were calculated as described in a previous study [37].