Table 2.
| ||||
---|---|---|---|---|
entry | base | Pd source | solvent | assay yield (%)a |
1 | LiN(SiMe3)2 | [PdCl(allyl)]2 | THF | 61 |
2 | LiN(SiMe3)2 | PdCl2(cod) | DME | 57 |
3 | LiN(SiMe3)2 | PdCl2(cod) | toluene | 35 |
4 | LiN(SiMe3)2 | PdCl2 | toluene | 0 |
5 | NaN(SiMe3)2 | Pd(OAc)2 | CPME | 56 |
6 | NaN(SiMe3)2 | PdCl2(cod) | CPME | 58 |
7 | NaN(SiMe3)2 | [PdCl(allyl)]2 | toluene | 45 |
Yields determined by 1H NMR analysis of crude mixture with CH2Br2 as internal standard.