Table 1.
Signal scores for statin-associated cancers
| Case | Non-cases | ROR | 95% CI | IC | 95% CI | |
|---|---|---|---|---|---|---|
| A: Colorectal cancer | ||||||
| Statins | 866 | 1,432,960 | 1.29 | 1.20-1.38 | 0.35 | 0.25-0.45 |
| Simvastatin | 208 | 487,029 | 0.90 | 0.79-1.03 | -0.15 | -0.35 to 0.05 |
| Rosuvastatin # | 87 | 177,676 | 1.03 | 0.84-1.28 | 0.05 | -0.26 to 0.36 |
| Atorvastatin # | 464 | 556,115 | 1.78 | 1.62-1.95 | 0.81 | 0.68-0.95 |
| Fluvastatin | 12 | 27,998 | 0.91 | 0.51-1.59 | -0.13 | -0.93 to 0.67 |
| Pitavastatin # | 4 | 5,420 | 1.56 | 0.58-4.16 | 0.49 | -0.80 to1.78 |
| Pravastatin | 68 | 122,700 | 1.17 | 0.92-1.49 | 0.22 | -0.12 to 0.57 |
| Lovastatin | 23 | 56,022 | 0.87 | 0.58-1.31 | -0.20 | -0.79 to 0.39 |
| B: Lung cancer | ||||||
| Statins | 1,566 | 1,432,260 | 0.96 | 0.92-1.01 | -0.05 | -0.13 to 0.02 |
| Simvastatin | 440 | 486,797 | 0.80 | 0.72-0.87 | -0.33 | -0.46 to -0.19 |
| Rosuvastatin # | 184 | 177,579 | 0.91 | 0.79-1.06 | -0.13 | -0.34 to 0.08 |
| Atorvastatin # | 728 | 555,851 | 1.16 | 1.08-1.24 | 0.21 | 0.10-0.32 |
| Fluvastatin | 28 | 27,982 | 0.88 | 0.61-1.28 | -0.17 | -0.71 to 0.36 |
| Pitavastatin # | 13 | 5,411 | 2.12 | 1.23-3.65 | 0.97 | 0.20-1.74 |
| Pravastatin | 127 | 122,641 | 0.91 | 0.77-1.09 | -0.13 | -0.39 to 0.13 |
| Lovastatin | 46 | 55,999 | 0.72 | 0.54-0.97 | -0.46 | -0.88 to -0.03 |
| C: Pancreatic cancer | ||||||
| Statins | 542 | 1,433,284 | 1.35 | 1.24-1.47 | 0.42 | 0.30-0.55 |
| Simvastatin | 190 | 487,047 | 1.39 | 1.20-1.60 | 0.46 | 0.25-0.67 |
| Rosuvastatin # | 67 | 177,696 | 1.34 | 1.05-1.70 | 0.41 | 0.06-0.76 |
| Atorvastatin # | 219 | 556,360 | 1.40 | 1.23-1.60 | 0.48 | 0.28-0.67 |
| Fluvastatin | 9 | 28,001 | 1.14 | 0.59-2.19 | 0.17 | -0.74 to 1.08 |
| Pitavastatin # | 3 | 5,421 | 1.96 | 0.63-6.09 | 0.66 | -0.78 to 2.10 |
| Pravastatin | 38 | 122,730 | 1.10 | 0.80-1.51 | 0.13 | -0.33 to 0.59 |
| Lovastatin | 16 | 56,029 | 1.01 | 0.62-1.65 | 0.02 | -0.68 to 0.72 |
| D: Gastric cancer | ||||||
| Statins | 204 | 1,433,622 | 0.92 | 0.80-1.06 | -0.11 | -0.32 to 0.09 |
| Simvastatin | 40 | 487,197 | 0.53 | 0.39-0.72 | -0.89 | -1.34 to -0.44 |
| Rosuvastatin # | 29 | 177,734 | 1.06 | 0.74-1.53 | 0.08 | -0.45 to 0.61 |
| Atorvastatin # | 86 | 556,493 | 1.00 | 0.81-1.24 | 0.01 | -0.31 to 0.32 |
| Fluvastatin | 9 | 28,001 | 2.09 | 1.09-4.02 | 0.91 | 0.00 - 1.83 |
| Pitavastatin # | 10 | 5,414 | 12.01 | 6.46-22.35 | 2.58 | 1.71-3.46 |
| Pravastatin | 26 | 122,742 | 1.38 | 0.94-2.02 | 0.44 | -0.12 to 1.00 |
| Lovastatin | 4 | 56,041 | 0.46 | 0.17-1.24 | -0.94 | -2.24 to 0.35 |
| E: Esophageal cancer | ||||||
| Statins | 134 | 1,433,692 | 1.06 | 0.89-1.26 | 0.08 | -0.17 to 0.34 |
| Simvastatin | 47 | 487,190 | 1.10 | 0.82-1.46 | 0.13 | -0.29 to 0.55 |
| Rosuvastatin # | 15 | 177,748 | 0.96 | 0.58-1.59 | -0.06 | -0.78 to 0.66 |
| Atorvastatin # | 52 | 556,527 | 1.06 | 0.81-1.39 | 0.08 | -0.32 to 0.48 |
| Fluvastatin | 0 | 28,010 | 0.00 | - | -1.79 | -4.68 to 1.09 |
| Pitavastatin # | 1 | 5,423 | 2.09 | 0.29-14.86 | 0.44 | -1.60 to 2.48 |
| Pravastatin | 14 | 122,754 | 1.30 | 0.77-2.19 | 0.34 | -0.40 to 1.09 |
| Lovastatin | 5 | 56,040 | 1.01 | 0.42-2.43 | 0.01 | -1.16 to 1.19 |
| F: Breast cancer (female) | ||||||
| Statins | 1,777 | 749,094 | 0.48 | 0.46-0.51 | -1.03 | -1.10 to -0.96 |
| Simvastatin | 505 | 239,204 | 0.43 | 0.40-0.47 | -1.19 | -1.32 to -1.07 |
| Rosuvastatin # | 257 | 100,684 | 0.53 | 0.46-0.59 | -0.92 | -1.10 to -0.74 |
| Atorvastatin # | 763 | 294,903 | 0.53 | 0.49-0.57 | -0.90 | -1.01 to -0.80 |
| Fluvastatin | 26 | 15,466 | 0.35 | 0.24-0.51 | -1.49 | -2.04 to -0.93 |
| Pitavastatin # | 4 | 2,712 | 0.30 | 0.11-0.81 | -1.50 | -2.79 to -0.21 |
| Pravastatin | 144 | 65,373 | 0.45 | 0.39-0.53 | -1.13 | -1.37 to -0.89 |
| Lovastatin | 78 | 30,752 | 0.52 | 0.42-0.65 | -0.92 | -1.25 to -0.60 |
| G: Hematological malignancies | ||||||
| Statins | 1,590 | 1,432,236 | 0.52 | 0.49-0.54 | -0.93 | -1.00 to -0.85 |
| Simvastatin | 544 | 486,693 | 0.53 | 0.48-0.57 | -0.92 | -1.04 to -0.79 |
| Rosuvastatin # | 178 | 177,585 | 0.47 | 0.41-0.55 | -1.07 | -1.29 to -0.86 |
| Atorvastatin # | 597 | 555,982 | 0.51 | 0.47-0.55 | -0.97 | -1.09 to -0.86 |
| Fluvastatin | 39 | 27,971 | 0.66 | 0.48-0.90 | -0.59 | -1.04 to -0.13 |
| Pitavastatin # | 13 | 5,411 | 1.14 | 0.66-1.96 | 0.17 | -0.60 to 0.94 |
| Pravastatin | 153 | 122,615 | 0.59 | 0.50-0.69 | -0.76 | -0.99 to -0.52 |
| Lovastatin | 66 | 55,979 | 0.56 | 0.44-0.71 | -0.83 | -1.18 to -0.48 |
| H: Melanoma | ||||||
| Statins | 298 | 1,433,528 | 0.90 | 0.80-1.01 | -0.14 | -0.31 to 0.02 |
| Simvastatin | 103 | 487,134 | 0.92 | 0.76-1.12 | -0.12 | -0.40 to 0.16 |
| Rosuvastatin # | 37 | 177,726 | 0.91 | 0.66-1.25 | -0.14 | -0.61 to 0.33 |
| Atorvastatin # | 118 | 556,461 | 0.92 | 0.77-1.11 | -0.12 | -0.38 to 0.15 |
| Fluvastatin | 5 | 28,005 | 0.78 | 0.32-1.87 | -0.31 | -1.49 to 0.87 |
| Pitavastatin # | 1 | 5,423 | 0.80 | 0.11-5.70 | -0.17 | -2.21 to 1.87 |
| Pravastatin | 21 | 122,747 | 0.74 | 0.48-1.14 | -0.41 | -1.02 to 0.21 |
| Lovastatin | 13 | 56,032 | 1.01 | 0.59-1.74 | 0.01 | -0.76 to 0.78 |
| I: Prostate cancer (male) | ||||||
| Statins | 823 | 642,806 | 1.25 | 1.17-1.34 | 0.31 | 0.21-0.42 |
| Simvastatin | 243 | 234,140 | 1.01 | 0.89-1.14 | 0.01 | -0.17 to 0.20 |
| Rosuvastatin # | 98 | 72,176 | 1.32 | 1.08-1.61 | 0.39 | 0.10-0.68 |
| Atorvastatin # | 340 | 243,152 | 1.36 | 1.22-1.52 | 0.44 | 0.28-0.60 |
| Fluvastatin | 15 | 12,013 | 1.21 | 0.73-2.01 | 0.26 | -0.46 to 0.98 |
| Pitavastatin # | 7 | 2,529 | 2.69 | 1.28-5.65 | 1.15 | 0.13-2.17 |
| Pravastatin | 78 | 122,690 | 0.62 | 0.49-0.77 | -0.69 | -1.01 to -0.36 |
| Lovastatin | 42 | 24,239 | 1.68 | 1.24-2.28 | 0.73 | 0.29-1.17 |
Case: Number of reports of cancer
Non-cases: All reports of adverse drug reactions other than cancer
ROR: Reporting odds ratio
CI: Confidence interval
IC: Information component
#: High potency statin