Table 3.
Symmetry analysis: Associations of statins with cancers
| Incident users |
Cases with cancer | Diagnosis of cancer last/first |
Adjusted SR | 95% CI | |||
|---|---|---|---|---|---|---|---|
| Lower | Upper | ||||||
| A: Colorectal cancer | |||||||
| Statins | 38,402 | 1,575 | 747 | 648 | 1.20 | 1.08 | 1.34 |
| Simvastatin | 2,118 | 85 | 43 | 32 | 1.06 | 0.66 | 1.73 |
| Rosuvastatin # | 17,515 | 742 | 311 | 353 | 0.95 | 0.81 | 1.11 |
| Atorvastatin # | 14,359 | 611 | 295 | 256 | 1.33 | 1.12 | 1.57 |
| Fluvastatin | 1,678 | 81 | 35 | 37 | 0.72 | 0.44 | 1.18 |
| Pitavastatin # | 8,942 | 381 | 184 | 154 | 1.32 | 1.06 | 1.65 |
| Pravastatin | 9,327 | 473 | 224 | 195 | 1.00 | 0.82 | 1.22 |
| B: Lung cancer | |||||||
| Statins | 38,402 | 818 | 396 | 313 | 1.32 | 1.13 | 1.53 |
| Simvastatin | 2,118 | 42 | 24 | 13 | 1.46 | 0.72 | 3.13 |
| Rosuvastatin # | 17,515 | 405 | 181 | 177 | 3.46 | 2.80 | 4.28 |
| Atorvastatin # | 14,359 | 312 | 144 | 129 | 1.28 | 1.01 | 1.64 |
| Fluvastatin | 1,678 | 48 | 22 | 18 | 0.94 | 0.48 | 1.85 |
| Pitavastatin # | 8,942 | 185 | 87 | 75 | 1.28 | 0.93 | 1.77 |
| Pravastatin | 9,327 | 225 | 113 | 88 | 1.12 | 0.84 | 1.50 |
| C: Pancreatic cancer | |||||||
| Statins | 38,402 | 804 | 388 | 293 | 1.31 | 1.13 | 1.53 |
| Simvastatin | 2,118 | 44 | 17 | 18 | 0.71 | 0.34 | 1.46 |
| Rosuvastatin # | 17,515 | 386 | 179 | 156 | 1.17 | 0.94 | 1.46 |
| Atorvastatin # | 14,359 | 303 | 147 | 110 | 1.47 | 1.14 | 1.90 |
| Fluvastatin | 1,678 | 45 | 22 | 16 | 1.00 | 0.50 | 2.04 |
| Pitavastatin # | 8,942 | 208 | 92 | 92 | 1.05 | 0.78 | 1.42 |
| Pravastatin | 9,327 | 221 | 113 | 88 | 1.07 | 0.80 | 1.43 |
| D: Gastric cancer | |||||||
| Statins | 38,402 | 1,333 | 595 | 568 | 1.04 | 0.93 | 1.17 |
| Simvastatin | 2,118 | 72 | 25 | 37 | 0.51 | 0.29 | 0.87 |
| Rosuvastatin # | 17,515 | 626 | 257 | 297 | 0.89 | 0.75 | 1.05 |
| Atorvastatin # | 14,359 | 538 | 225 | 239 | 1.04 | 0.86 | 1.25 |
| Fluvastatin | 1,678 | 83 | 34 | 40 | 0.62 | 0.38 | 1.01 |
| Pitavastatin # | 8,942 | 307 | 122 | 147 | 0.88 | 0.69 | 1.12 |
| Pravastatin | 9,327 | 339 | 107 | 80 | 1.12 | 0.83 | 1.51 |
| E: Esophageal cancer | |||||||
| Statins | 38,402 | 125 | 68 | 45 | 1.38 | 0.93 | 2.05 |
| Simvastatin | 2,118 | 3 | 2 | 1 | 1.38 | 0.07 | 81.45 |
| Rosuvastatin # | 17,515 | 57 | 32 | 21 | 1.42 | 0.79 | 2.58 |
| Atorvastatin # | 14,359 | 65 | 28 | 30 | 0.95 | 0.55 | 1.64 |
| Fluvastatin | 1,678 | 7 | 4 | 2 | 1.34 | 0.19 | 14.76 |
| Pitavastatin # | 8,942 | 38 | 22 | 14 | 1.52 | 0.74 | 3.21 |
| Pravastatin | 9,327 | 24 | 11 | 9 | 0.93 | 0.35 | 2.55 |
| F: Breast cancer (female) | |||||||
| Statins | 15,694 | 485 | 195 | 239 | 0.81 | 0.66 | 0.98 |
| Simvastatin | 971 | 18 | 4 | 12 | 0.25 | 0.06 | 0.83 |
| Rosuvastatin # | 7,075 | 227 | 87 | 119 | 0.74 | 0.56 | 0.99 |
| Atorvastatin # | 5,756 | 176 | 68 | 85 | 0.90 | 0.64 | 1.25 |
| Fluvastatin | 756 | 31 | 17 | 11 | 1.12 | 0.50 | 2.65 |
| Pitavastatin # | 3,542 | 118 | 43 | 60 | 0.75 | 0.49 | 1.13 |
| Pravastatin | 4,283 | 128 | 54 | 63 | 0.73 | 0.50 | 1.07 |
| G: Hematological malignancies | |||||||
| Statins | 38,402 | 373 | 156 | 171 | 0.90 | 0.72 | 1.12 |
| Simvastatin | 2,118 | 21 | 9 | 12 | 0.56 | 0.21 | 1.44 |
| Rosuvastatin # | 17,515 | 161 | 68 | 77 | 0.89 | 0.63 | 1.25 |
| Atorvastatin # | 14,359 | 165 | 64 | 84 | 0.83 | 0.59 | 1.16 |
| Fluvastatin | 1,678 | 19 | 10 | 9 | 0.80 | 0.29 | 2.22 |
| Pitavastatin # | 8,942 | 80 | 32 | 35 | 0.95 | 0.57 | 1.58 |
| Pravastatin | 9,327 | 92 | 35 | 47 | 0.61 | 0.38 | 0.97 |
| H: Melanoma | |||||||
| Statins | 38,402 | 34 | 20 | 14 | 1.15 | 0.55 | 2.46 |
| Simvastatin | 2,118 | 0 | 0 | 0 | - | - | - |
| Rosuvastatin # | 17,515 | 18 | 9 | 9 | 0.61 | 0.21 | 1.72 |
| Atorvastatin # | 14,359 | 13 | 7 | 5 | 1.26 | 0.35 | 5.05 |
| Fluvastatin | 1,678 | 2 | 0 | 2 | 0.00 | - | - |
| Pitavastatin # | 8,942 | 12 | 7 | 5 | 1.20 | 0.33 | 4.78 |
| Pravastatin | 9,327 | 7 | 4 | 3 | 0.90 | 0.15 | 6.15 |
| I: Prostate cancer (male) | |||||||
| Statins | 22,708 | 522 | 231 | 231 | 1.16 | 0.96 | 1.40 |
| Simvastatin | 1,147 | 33 | 11 | 18 | 0.53 | 0.23 | 1.19 |
| Rosuvastatin # | 10,440 | 247 | 103 | 119 | 1.04 | 0.79 | 1.36 |
| Atorvastatin # | 8,603 | 229 | 100 | 105 | 1.20 | 0.90 | 1.60 |
| Fluvastatin | 922 | 27 | 13 | 12 | 0.92 | 0.38 | 2.19 |
| Pitavastatin # | 5,400 | 154 | 72 | 67 | 1.33 | 0.94 | 1.88 |
| Pravastatin | 5,044 | 143 | 66 | 58 | 1.08 | 0.74 | 1.56 |
Incident users: Number of patients who received their first prescription for statins
Cases with cancer: Number of patients newly diagnosed with cancer
Diagnosis of cancer last: Diagnosis of cancer last indicates the number of patients with a diagnosis after statin use
Diagnosis of cancer first: Diagnosis of cancer first indicates the number of patients with a diagnosis before statin use
Adjusted SR: Adjusted sequence ratio
CI: Confidence interval
#: High potency statin