Table 1.

List of completed clinical trials using ex vivo expanded MSCs.

Clinical trial No.	Source of MSCS	Serum Supplement	Disease Treated	Dose No. of treatment	Route of Administration	Phase	Design	References
NCT00395200	Au BM	FBS	Multiple Sclerosis	1-2 ×106 cells/ kg BW Single	Intravenous	I & II	Non-randomized, Safety/efficacy study, Single group assignment, Open label	41, 42
NCT00504803	Allo BM	Irradiated FBS	Graft-versus-host-disease	- Single	Intravenous	II	Non-randomized, Safety/efficacy study, Single group assignment, Open label	43
NCT01087996	Au BM Allo BM	-	Ischemic cardiomyopathy	20/100/200 ×106 cells Single	Transendocardial	I & II	Randomized, Safety/efficacy study, Parallel assignment, Open label	44
NCT00114452	Allo BM	-	Myocardial infarction	0.5/1.6/5 ×106 cells / kg BW Single	Intravenous	I	Randomized, Safety study, Parallel assignment, Double blind (Subject, Caregiver, Investigator, Outcomes assessor)	45
NCT00658073	Au BM	-	Renal transplant rejection	1-2×106 cells/ kg BW Twice	Intravenous	-	Randomized, Efficacy study, Parallel assignment, Open label	46
NCT00734396	Au BM	FBS	Renal transplant rejection	1×106 cells/ kg BW Twice	Intravenous	I & II	Non-randomized, Safety/efficacy study, Single group assignment, Open label	47
NCT00883870	Allo BM	-	Critical limb ischemia	2×106 cells/kg BW Single	Intramuscular (gastrocnemius muscle)	I & II	Randomized, Safety/efficacy study, Parallel assignment, Double blind (Subject, caregiver, investigator)	48
NCT00823316	Allo UCB	FBS	Graft rejection and graft-versus-host-disease	1 & 5 ×106 cells/ kg BW Single	Intravenous	I & II	Randomized, Safety/efficacy study, Parallel assignment, Open label	49
NCT00911365	Au BM	FBS	Multiple system atrophy	40×106 cells Multiple	Intra arterial (1 time) Intravenous (3 times)	II	Randomized, Parallel assignment, Single blind (subject)	50
NCT01274975	Au AD	FBS	Spinal cord injury	400×106 cells Single	Intravenous	I	Randomized, Safety study, Single group assignment, Open label	51
NCT00683722	Allo BM	-	Coronary obstructive pulmonary disorder.	100×106 cells Multiple	Intravenous	II	Randomized, Safety/efficacy study, Parallel assignment, Double blind (subject, caregiver, investigator, outcomes assessor)	52
NCT00956891	Au BM	FBS	Liver failure	≈100×106 cells Single	Hepatic artery	-	Case Control, retrospective	53
NCT00187018	Allo BM	FBS	Osteogenesis imperfecta	0.68-2.75×103 cells/kg BW Single	Intravenous	-	Non-Randomized, Safety/Efficacy Study, Single Group Assignment, Open Label	54
NCT00816803	Au BM	Serum free	Spinal cord injury	2×106 cells/ kg BW Multiple	Lumbar puncture	I & II	Safety/Efficacy Study, Parallel Assignment, Single Blind (Outcomes Assessor)	55

Au, Autologous; Allo, Allogeneic; BM, Bone marrow; UCB, Umbilical cord blood; AD, Adipose derived.