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. 2015 Feb 8;11(3):353–360. doi: 10.7150/ijbs.9813

Figure 1.

Figure 1

LV delivery efficacy and inhibition efficiency. Three different titers of LV-shGadd45b were injected 7 d before MCAO through stereotactic surgery. (A) A few GFP-positive cells were localized in the cortex and hippocampus injected with low-titer LVs. A large number of GFP-positive cells were observed in the cortex and hippocampus injected with medium- and high-titer LVs. (B) Gadd45b-shRNA treatment effectively suppressed MCAO-induced Gadd45b expression. Data were expressed as fold of sham. (C) Immunohistochemistry for Gadd45b (original magnification 400×). Images are taken from ipsilateral ischemic penumbra. (D) The bar graph reflects the Gadd45b-positive cells in each group. (*p<0.01, compared with sham group, #p<0.01, compared with LV-shGadd45b group).