Figure 7.

Schematic model of the protective effect of sirtuin 1 against ischemia-reperfusion injury associated to rat orthotopic liver transplantation. Trimetazidine (TMZ) addition to IGL-1 promotes NAMPT expression and enhances NAD+ levels, which in turn provokes SIRT1 up-regulation. SIRT1 contributes to decreased hepatic injury by inhibiting mitochondrial damage and oxidative stress, activating autophagic pathway and by enhancing p-ERK and decreasing p-p38 protein expression. SIRT1: Sirtuin 1; IRI: Ischemia-reperfusion injury; OLT: Orthotopic liver transplantation.