FIG 2.

Impaired function and substrate metabolism in hearts from mice with constitutive activation of Akt in cardiomyocytes (caAkt). (A) Dry heart weight-to-body weight ratio (DHW/BW) in caAkt and WT mice (n = 4). (B to F) Cardiac power (B), glycolysis (C), glucose oxidation (D), palmitate oxidation (P = 0.08) (E), and MVO₂ (F) in isolated working hearts from 18-week-old WT and caAkt mice (n = 4). (G) Representative electron micrographs of cardiac tissue from 18-week-old WT and caAkt mice. (H and I) Mitochondrial volume density (H) and mitochondrial number (I) per high-power field (hpf) in electron micrographs of 6- and 18-week-old WT and caAkt hearts (n = 3 or 4). Data are shown as mean ± SEM. *, P < 0.05 versus WT of same age.