TABLE 2.
LV catheterization for hemodynamic parameters and organ weights in WT and caAkt mice (6 weeks)
| Parametera | Value |
|
|---|---|---|
| WT | caAktb | |
| Arterial SP (mm Hg) | 103.8 ± 2.4 | 65.9 ± 4.9* |
| Arterial DP (mm Hg) | 76.3 ± 2.0 | 48.1 ± 6.0* |
| LV SP (mm Hg) | 98.2 ± 3.0 | 62.1 ± 4.4* |
| LV EDP (mm Hg) | 11.6 ± 1.8 | 23.6 ± 2.0* |
| LV DevP (mm Hg) | 98.5 ± 2.6 | 53.0 ± 3.4* |
| +dP/dt (mm Hg/s) | 9,381 ± 921 | 2,670 ± 216* |
| −dP/dt (mm Hg/s) | −8,227 ± 562 | −3,002 ± 207* |
| HR (beats/min) | 528 ± 6 | 482 ± 17* |
| Body wt (g) | 21.6 ± 0.6 | 20.8 ± 0.7 |
| Heart wt (mg) | 96.2 ± 2.6 | 182.4 ± 1.5* |
| HW/BW | 4.45 ± 0.07 | 8.81 ± 0.15* |
| LW/BW | 7.31 ± 0.27 | 9.00 ± 0.39* |
a
SP, systolic pressure; DP, diastolic pressure; LV, left ventricular; EDP, end-DP; DevP, developed pressure; +dP/dt, peak rate of LV pressure rise; −dP/dt, peak rate of LV pressure decline; HR, heart rate; HW, heart weight; BW, body weight; LW, lung weight.
b
*, P < 0.05 versus wild type (WT); n = 7.