TABLE 5.
LV catheterization for hemodynamic parameters and organ weights in control and tON-Akt mice (7 to 10 days)
| Parametera | Valueb |
|
|---|---|---|
| Control | tON-Akt | |
| Arterial SP (mm Hg) | 98.0 ± 5.2 | 71.5 ± 5.5* |
| Arterial DP (mm Hg) | 72.4 ± 4.0 | 52.0 ± 4.2* |
| LV SP (mm Hg) | 93.8 ± 3.6 | 76.5 ± 6.0* |
| LV EDP (mm Hg) | 13.9 ± 2.4 | 20.2 ± 10.0* |
| LV DevP (mm Hg) | 92.8 ± 3.5 | 69.1 ± 9.4* |
| +dP/dt (mm Hg/s) | 9,148 ± 867 | 5,257 ± 849* |
| −dP/dt (mm Hg/s) | −7,905 ± 458 | −4,048 ± 427* |
| HR (beats/min) | 497 ± 28 | 440 ± 14 |
| Body wt (g) | 21.6 ± 0.6 | 21.7 ± 0.6 |
| Heart wt (mg) | 101.1 ± 2.6 | 308.5 ± 12.5* |
| HW/BW | 4.70 ± 0.15 | 14.32 ± 0.75* |
| LW/BW | 7.47 ± 0.22 | 9.22 ± 0.36* |
a
SP, systolic pressure; DP, diastolic pressure; LV, left ventricular; EDP, end-DP; DevP, developed pressure; +dP/dt, peak rate of LV pressure rise; −dP/dt, peak rate of LV pressure decline; HR, heart rate; HW, heart weight; BW, body weight; LW, lung weight.
b
*, P < 0.05 versus control; n = 6 to 9.