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. 2015 Feb 11;35(6):2358–2371. doi: 10.1523/JNEUROSCI.5791-12.2015

Figure 7.

Figure 7.

Klotho elevation increases GluN2B levels in hippocampal PSD fractions of hAPP mice. Non-PSD (1) and PSD (2) synaptic membrane fractions were isolated from hippocampal homogenates from mice of the indicated genotypes (n = 6–14 per genotype, age 3 months). A, Representative Western blots. B, Quantitation of GluN2B Western blot signals in the non-PSD fraction relative to NTG levels. Two-way ANOVA: hAPP effect p < 0.01; *p < 0.05 versus NTG, #p = 0.06 versus KL (Bonferroni-Holm test). C, Quantitation of GluN2B signals in PSD fraction relative to NTG levels. Two-way ANOVA: KL effect p < 0.05; *p < 0.05 versus NTG or as indicated by bracket (Bonferroni-Holm test). D, Ratio of PSD/non-PSD GluN2B levels in hAPP and hAPP/KL mice relative to ratio in hAPP mice; *p < 0.05 (t test). Bar graphs represent mean ± SEM.