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. 2015 Feb 11;35(6):2417–2422. doi: 10.1523/JNEUROSCI.3279-14.2015

Figure 4.

Figure 4.

Microglial process convergence requires microglial P2Y12 receptors. A, Schematic showing MPCs in the presence of ATP (1 mm; n = 5 slices) and in P2Y12 knock-out mouse slices (n = 8 slices) during calcium reduction. B, A sample initiating MPC that fails to be terminated upon application of ATP (asterisk indicates presumptive foci). C, D, MPC occurrence (C) and microglial density (D) in P2Y12 wild-type, heterozygote, and knock-out slices. E, F, Quantitative data showing effects of P2X7 antagonists (BBG; 10–20 μm; n = 5 slices), connexin blocker (CBX, 100 μm; n = 4 slices), and pannexin channel blocker (PB, 5 mm; n = 6 slices) on the occurrence of these events (D) and distance of responding microglia from the process convergence focal point (E); *p < 0.05, Student's t test; ***p < 0.001, ANOVA.