Figure 3.

PTSD-like phenotype requires Crfr1. A, Wild-type (blue) and APP/hAβ/PS1 (red) animals were crossed into a Crfr1^−/− background. In resulting mice, PTSD-like induction (darker bars) did not alter anxiety-related behavior or acoustic startle in either genotype. Data have been normalized to scores for wild-type, unstressed animals for each test (wild-type Crfr1^−/− control, n = 6; wild-type Crfr1^−/− stress, n = 5; APP/hAβ/PS1;Crfr1^−/− control, n = 14; APP/hAβ/PS1;Crfr1^−/− stress, n = 18). B, CSF Aβ levels were measured in APP/hAβ/PS1;Crfr1^−/− animals at both a young (3–4 months) and old (6–12 months) time point. PTSD-like induction did not alter Aβ levels when animals lacked Crfr1 (young APP/hAβ/PS1;Crfr1^−/−, n = 5 per condition; old APP/hAβ/PS1;Crfr1^−/−, n = 5 control, n = 6 stress).