Figure 6.

γ-Secretase inhibitors reverse PTSD-like phenotypes in APP/hAβ/PS1 animals. A, Treatment with SEMA during PTSD-like trauma exposure did not significantly alter behavior on the LDT test. B, SEMA decreased acoustic startle to a 120 dB sound. C, SEMA increased center/total distance traveled in the OFA. D, SEMA treatment decreased peak corticosteroid levels observed in trauma-exposed animals 2 weeks after the stress (for A–D, vehicle, n = 17; SEMA, n = 14). E, CSF sampled from unstressed APP/hAβ/PS1 animals after receiving 3 d of SEMA injections contained less Aβ₄₀ compared with vehicle controls (n = 7 per treatment).