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. Author manuscript; available in PMC: 2016 Feb 25.
Published in final edited form as: Vaccine. 2015 Jan 17;33(9):1102–1106. doi: 10.1016/j.vaccine.2015.01.026

Figure 3. Vaccination with inactivated H10N8 virus, rH10 and rN8 protects mice from viral challenge.

Figure 3

Weight loss A and survival B of animals that received an intramuscular prime-boost regimen with inactivated H10N8, rH10 or rN8 vaccines. C ELISA titers of vaccinated animals against purified JD13 H10N8 virus. Sera from rH10 or rN8 can only react to one component of the virus while sera from animals vaccinated with inactivated virus or exposed to a sublethal infection react to both surface glyoproteins and to the internal proteins of damage virions on the ELISA plate as well. D shows HI and NI titers against JD13 H10N8 virus as well as NI titers against a heterologous H3N8 isolate. 1The virus strain used for this assay was A/Northern shoveler/Alaska/7MP1708/07 (H3N8). 2Geometric mean plus range in parenthesis, negative wells were assigned a value of 5 for calculation purpose. 3Values are expressed as the reciprocal serum dilution that was able to inhibit NA activity by 50%. 4Anti-HA antibodies can cause low titers of NI activity by steric hindrance [20].