Table 3. Associated SNPs (p < 0.05) in the genetic association of single SNPs with POAG in the study population using logistic regression modeling with the justification of age and gender. None withstood Bonferroni correction for multiple comparisons (p < 0.00025).
| Genomic region | SNP | MA | MAF POAG | MAF Controls | p | OR (95% CI) |
|---|---|---|---|---|---|---|
| COL8A2 | rs6693322 | G | 0.107 | 0.070 | 0.0139 | 1.92 (1.14–3.24) |
| MYOC | rs235917 | A | 0.084 | 0.040 | 0.0140 | 2.32 (1.19–4.52) |
| COL1A1 | rs16948744 | G | 0.370 | 0.437 | 0.0143 | 0.68 (0.5–0.93) |
| ZNF469 | rs9925231 | A | 0.502 | 0.428 | 0.0225 | 1.43 (1.05–1.93) |
MA, minor allele; MAF, minor allele frequency; OR (95% CI), Odds ratio (95% confidence intervals).