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Study design. Transgene expression in the condSCA1[82Q] mice was suppressed with doxycycline administration in drinking water with sucrose from 12–24 weeks in the treatment group. Transgenic, untreated littermates received sucrose water during the same period to match sugar intake and wild type (WT, tTA background) mice received doxycycline in sucrose water. The gene on periods are shown with a bold line.
