Table 1.
Baseline characteristics of WIHS participants by HIV Status
| Parameter | HIV-infected (n=2621*) | HIV-uninfected (n=941) | P-value |
|---|---|---|---|
| Baseline Age (median, range) | 38 (19-80) | 37 (18-73) | <.0001 |
| Age<30 | 200 (8%) | 194 (21%) | |
| Age 30-40 | 1534 (59%) | 500 (53%) | |
| Age 40-50 | 751 (29%) | 217 (23%) | |
| Age>50 | 136 (5%) | 30 (3%) | |
| Race | |||
| African American | 1513 (58%) | 539 (57%) | 0.97 |
| Caucasian | 604 (23%) | 220 (23%) | |
| Other | 498 (19%) | 180 (19%) | |
| Cigarette smoking | |||
| Current | 1273 (49%) | 514 (55%) | 0.0049 |
| Past | 548 (21%) | 182 (19%) | |
| Never | 800 (31%) | 245 (26%) | |
| BMI (kg/m2) | 26 (23-31) | 28 (24-34) | <.0001 |
| Waist Circumference (cm) | 89 (80-101) | 91 (80-104) | 0.063 |
| Parity | |||
| 0-1 | 1010 (39%) | 426 (45%) | 0.0016 |
| 2 | 570 (22%) | 185 (20%) | |
| 3+ | 1037 (40%) | 329 (35%) | |
| Gravidity | |||
| 0-1 | 297 (11%) | 174 (19%) | <.0001 |
| 2-4 | 822 (31%) | 276 (29%) | |
| 5+ | 1497 (57%) | 489 (52%) | |
| Hormonal Contraceptive Use (current) | 176 (7%) | 85 (9%) | 0.024 |
| Hormonal Contraceptive Use (Ever) | 532 (20%) | 285 (30%) | <.0001 |
| Hx of Irregular Menses | 1555 (59%) | 643 (68%) | <.0001 |
| Hx of Amenorrhea | 1752 (67%) | 743 (79%) | <.0001 |
| Age at Menarche | 12 (11-14) | 12 (11-13) | 0.011 |
| Crack/cocaine use | 394 (15%) | 177 (19%) | 0.0071 |
| Hepatitis C | 748 (29%) | 156 (17%) | <.0001 |
| Hx of Weight Loss | 973 (37%) | 169 (18%) | <.0001 |
| Current CD4 (/ml) | 359 (191-564) | 1008 (803-1270) | <.0001 |
| Nadir CD4 (/ml) | 273 (128-423) | 850 (651-1069) | <.0001 |
| Current CD8 (/ml) | 755 (519-1066) | 516 (387-664) | <.0001 |
| Nadir CD8 (/ml) | 589 (394-859) | 435 (323-576) | <.0001 |
| Current Total WBC (×103/ml) | 4.4 (3.4-5.6) | 6.4 (5.1-7.9) | <.0001 |
| Nadir Total WBC (×103/ml) | 3.7 (2.8-4.6) | 5.5 (4.5-6.8) | <.0001 |
| Current Total Lymphocyte/ml | 152 (108-201) | 205 (167-255) | <.0001 |
| Nadir Total Lymphocyte/ml | 122 (85-165) | 178 (140-220) | <.0001 |
| Plasma HIV RNA (copies/ml) | |||
| ≤80 | 619 (24%) | ||
| 81-1999 | 432 (17%) | ||
| 2000-9999 | 421 (16%) | ||
| >10000 | 1126 (43%) | ||
| Current HAART use | 829 (32%) |
Data are presented as Median (IQR) or numbers (percent).
Abbreviations: IQR, interquartile range; Hx, history; WBC, white blood cell
*
HIV+ sample size is slightly larger in the longitudinal analyses below due to seroconversion