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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Math Biosci. 2014 Dec 9;261:48–61. doi: 10.1016/j.mbs.2014.11.004

Figure 8. Sensitivity analysis of the monoexponential FCR.

Figure 8

The time derivative of the logarithm of the labeling time course was previously used to estimate ‘clearance’ kinetics between 24 and 36 hours (reference [7]). (A) The time derivative of −ln(pAb42d3L) is the instantaneous ‘monoexponential slope’ or FCR is shown for each subject. This is relatively constant for the non-carrier between 24 and 36 hours, but varies considerably for the mutation carrier. (B&C) The sensitivity of d(–ln(pAb42d3L))/dt to changes in parameter values was evaluated. Also plotted are the measured (‘Meas p’) and predicted (‘Model p’) fractional labeling, scaled by 4 for readability. (B) Presenilin-1 mutation carrier with plaques validated by PET PIB scans, (C) Non-carrier without plaques.