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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Curr Opin Microbiol. 2014 Nov 5;0:8–13. doi: 10.1016/j.mib.2014.10.005

Figure 1. Architectural and regulatory logic of the PhoP regulon.

Figure 1

The PhoP regulon contains both ancestral and horizontally-acquired genes, a few of which are depicted here. Promoter architecture, i.e. the position and orientation of a transcription factor binding site (green arrows) relative to the transcription start site (TSS; bent arrow) of horizontally-acquired genes, is variable. Horizontally-acquired genes lacking conserved promoter architecture are not directly activated, as they do not permit an appropriate interaction between PhoP and RNAP. Genes exhibiting ancestral architecture are directly activated by PhoP, including those that have been horizontally-acquired (orgB). Blue boxes indicate the approximate positions of the −10 and −35 boxes. The figure is based on results presented elsewhere [5, 41, 42].