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Downregulation of the PI3K pathway and Akt activity after cabozantinib treatment. (A) A depiction of the PI3K pathway after 3 days of treatment with cabozantinib: red shows genes that are downregulated. (B) Evaluation of Akt activation by western blot in 4 CRC sensitive explants. Cabozantinib inhibited Akt activation in CRC explants.
