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. 2014 Sep 18;3(5):e001082. doi: 10.1161/JAHA.114.001082

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 2. — Association of circulating FGF‐23 concentrations with incidence of atrial fibrillation presented as hazard ratio (HR; solid line) and 95% confidence intervals (CI; shaded area). Results from Cox proportional hazards model with FGF‐23 modeled using restricted cubic splines, adjusted for age, sex, and race (top panel) and additionally adjusted for study site, body mass index, smoking, education, height, diabetes, systolic and diastolic blood pressure, use of antihypertensive medication, prevalent coronary heart disease, prevalent heart failure, ECG‐based left ventricular hypertrophy, NT‐proBNP, high‐sensitivity C‐reactive protein, and eGFR (bottom panel). Median value of FGF‐23 was considered the reference (HR=1). The histograms represent the frequency distribution of FGF‐23 in the study sample. Atherosclerosis Risk in Communities Study, 1990–2010. eGFR indicates estimated glomerular filtration rate; FGF, fibroblast growth factor; NT‐proBNP, N‐terminal prohormone of brain natriuretic peptide.