Table 3.
Health Utilities and Costs With Ranges Used in Sensitivity Analyses
| Value | Low | High | Distribution | |
|---|---|---|---|---|
| Health state utilities | ||||
| Atrial fibrillation | 0.998 | 0.665 | 1 | Beta |
| ICH | 0.189 | 0.126 | 0.252 | Beta |
| Major stroke 1st year | 0.3 | 0.2 | 0.4 | Beta |
| Major stroke 2nd year | 0.4 | 0.27 | 0.53 | Beta |
| Abnormal renal function | 0.58 | 0.39 | 0.77 | Beta |
| Heart failure | 0.63 | 0.61 | 0.65 | Beta |
| Hypertension | 0.72 | 0.71 | 0.73 | Beta |
| Minor stroke 1 month | 0.75 | 0.5 | 1 | Beta |
| Vascular disease | 0.8 | 0.53 | 1 | Beta |
| Diabetes mellitus | 0.84 | 0.56 | 1 | Beta |
| MI 1st year | 0.87 | 0.67 | 1 | Beta |
| MI 2nd year | 0.94 | 0.62 | 1 | Beta |
| MI thereafter | 0.95 | 0.63 | 1 | Beta |
| Abnormal liver function | 0.92 | 0.61 | 1 | Beta |
| Utility decrement warfarin | 0.013 | 0 | 0 | Beta |
| Utility decrement dabigatran | 0.006 | 0 | 0 | Beta |
| Utility decrement aspirin | 0.002 | 0 | 0 | Beta |
| Utility decrement major bleed | 0.159 | 0 | 0 | Beta |
| Utility decrement pericardial effusion | 0.159 | 0 | 0 | Beta |
| Utility decrement device embolization | 0.25 | 0 | 0 | Beta |
| Utility decrement procedure‐related stroke | 0.25 | 0 | 0 | Beta |
| Utility decrement LAA implant | 0.06 | 0 | 0 | Beta |
| Costs | ||||
| Medication costs (monthly) | ||||
| Warfarin | $36 | 24 | 48 | Gamma |
| Dabigatran | $99 | — | — | — |
| Aspirin | $0.93 | 0.62 | 1.23 | Gamma |
| Aspirin plus clopidogrel | $31 | 21 | 42 | Gamma |
| Transitional 1‐time costs | ||||
| Stroke (major minor, TIA) | $6595 | 12 | 13 178 | Gamma |
| ICH | $15 190 | 10 127 | 20 253 | Gamma |
| Major bleed | $4890 | 3260 | 6520 | Gamma |
| Minor bleed | $77 | 51 | 102 | Gamma |
| MI | $8972 | 122 | 17 822 | Gamma |
| Ongoing monthly costs | ||||
| ICH | $6335 | 4223 | 8446 | Gamma |
| Major stroke | $6001 | 4001 | 8001 | Gamma |
| Minor stroke | $2745 | 1830 | 3660 | Gamma |
| MI | $317 | 211 | 422 | Gamma |
| LAA occlusion device costs | ||||
| Unit cost per device | $8500 | 6800 | 10 200 | Gamma |
| Anesthesia fee | $500 | — | — | — |
| Nursing fee | $1700 | 1500 | 2000 | Gamma |
| Physician fee | $456 | — | — | — |
| 1 night hospitalization | $1773 | — | — | — |
| TEE at procedure | $211 | — | — | — |
| 6‐week/month TEE | $303 | — | — | Gamma |
| LAA occlusion device complications | ||||
| Pericardial effusion | $9900 | 6600 | 13 200 | Gamma |
| Device embolization | $26 428 | 17 618 | 35 237 | Gamma |
| Procedure‐related stroke | $6595 | 12 | 13.178 | Gamma |
ICH indicates intracranial hemorrhage; LAA, left atrial appendage; MI, myocardial infarction; TEE, transesophageal echocardiogram; TIA, transient ischemic attack.