Table 4.
Plasma microRNAs Significantly Altered in Both Ruptured and Unruptured IA Patients as Determined With Microarray
| Unruptured | Ruptured | |||||
|---|---|---|---|---|---|---|
| Regulation | Fold Change | P Value | Regulation | Fold Change | P Value | |
| let‐7a | Up | 18.4 | 0.037 | Up | 21.9 | 0.004 |
| let‐7c | Up | 14.6 | 0.049 | Up | 23.0 | 0.005 |
| let‐7d* | Up | 11.4 | 0.040 | Up | 21.7 | 0.004 |
| let‐7f* | Up | 11.5 | 0.049 | Up | 12.1 | 0.008 |
| let‐7 g | Up | 22.0 | 0.043 | Up | 35.1 | 0.006 |
| miR‐1183 | Up | 12.5 | 0.043 | Up | 52.7 | 0.002 |
| miR‐1234* | Down | 2.1 | 0.025 | Down | 1.9 | 0.011 |
| miR‐1280 | Down | 5.6 | 0.024 | Down | 5.8 | 0.004 |
| miR‐1281* | Down | 7.5 | 0.013 | Down | 4.4 | 0.006 |
| miR‐16* | Up | 10.5 | 0.043 | Up | 25.0 | 0.005 |
| miR‐1825* | Down | 7.6 | 0.002 | Down | 6.2 | 0.004 |
| miR‐188‐5p* | Up | 9.1 | 0.018 | Up | 24.3 | 0.002 |
| miR‐18a* | Up | 5.1 | 0.043 | Up | 18.7 | 0.001 |
| miR‐25* | Up | 9.5 | 0.049 | Up | 27.5 | 0.005 |
| miR‐425* | Down | 4.0 | 0.040 | Down | 4.0 | 0.006 |
| miR‐486‐3p* | Up | 5.0 | 0.042 | Up | 7.3 | 0.004 |
| miR‐486‐5p* | Up | 6.9 | 0.040 | Up | 25.0 | 0.004 |
| miR‐590‐5p | Up | 4.0 | 0.013 | Up | 13.0 | 0.001 |
| miR‐660* | Up | 6.4 | 0.037 | Up | 20.3 | 0.003 |
| miR‐7 | Up | 5.8 | 0.018 | Up | 16.8 | 0.003 |
Adjusted P values with Benjamini and Hochberg False Discovery Rate multiple testing correction were shown. IA indicates intracranial aneurysm.
*
These miRNAs were validated by the secondary microarray test with the expanded cohort.