Table 3.
Effect of Categorical Variables on Maximum Thrombin‐Induced Platelet‐Fibrin Clot Strength
| Variable | Clopidogrel‐Naïve | On Clopidogrel | ||
|---|---|---|---|---|
| F | P Value | F | P Value | |
| Sex | 46 | <0.0001 | 43 | <0.0001 |
| Race | 4.3 | 0.04 | 5.4 | 0.02 |
| Diabetes mellitus | 23.2 | <0.0001 | 15.2 | <0.0001 |
| Hypertension | 5.6 | 0.02 | 5.1 | 0.02 |
| History of smoking | 0.4 | 0.7 | 0.3 | 0.8 |
| Hyperlipidemia | 0.1 | 0.8 | 0 | 1 |
| Significant CAD* | 0.7 | 0.5 | 0.1 | 0.9 |
| Family history of CAD | 1.4 | 0.3 | 0.1 | 0.9 |
| History of PCI | 0.8 | 0.4 | 0.2 | 0.7 |
| History of CABG | 0.02 | 0.9 | 0.2 | 0.6 |
| History of MI | 0.7 | 0.4 | 0.4 | 0.5 |
| History of stroke | 0.1 | 0.8 | 0 | 1 |
| PAD | 1.1 | 0.3 | 0.4 | 0.5 |
| Chronic renal insufficiency* | 3.5 | 0.07 | 1.3 | 0.2 |
| Beta blockers | 0.9 | 0.4 | 5.6 | 0.02 |
| Statins | 1 | 0.4 | 0.4 | 0.8 |
| ACE inhibitors or ARBs | 0.4 | 0.6 | 1.3 | 0.25 |
| Calcium blockers | 8.6 | 0.001 | 2.5 | 0.08 |
| PPIs | 0.9 | 0.5 | 0.5 | 0.8 |
| Nitrates | 0.7 | 0.5 | 0.1 | 0.9 |
Analyses performed by multivariate analysis of variance. ACE indicates angiotensin‐converting enzyme; ARB, angiotensin II receptor blocker; CABG, coronary artery bypass grafting; CAD, coronary artery disease; MI, myocardial infarction; PAD, peripheral arterial disease; PCI, percutaneous coronary intervention; PPI, proton pump inhibitor.
*
At least 1 coronary artery with ≥50% stenosis according to current angiogram.
†Creatinine ≥1.5 mg/dL.