Table 4.
Association of GlycA and hsCRP With Incident Cardiovascular Disease by Follow‐Up Time
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P Linear Trend | Per 1 SD* | P Value | |
|---|---|---|---|---|---|---|---|
| Follow‐up during 1st 6 years (no. events=422) | |||||||
| GlycA | |||||||
| Range, μmol/L | ≤326 | 327 to 369 | 370 to 416 | ≥417 | |||
| Incidence rate per 1000 person‐years | 1.2 | 1.8 | 2.4 | 5.1 | |||
| Basic model | 1 | 1.18 (0.80 to 1.72) | 1.36 (0.95 to 1.95) | 2.17 (1.54 to 3.07) | <0.0001 | 1.34 (1.22 to 1.48) | <0.0001 |
| Basic model plus lipids | 1 | 1.06 (0.72 to 1.55) | 1.13 (0.78 to 1.63) | 1.68 (1.17 to 2.40) | 0.0003 | 1.24 (1.12 to 1.38) | <0.0001 |
| Basic model plus lipids plus hsCRP | 1 | 1.02 (0.69 to 1.49) | 1.05 (0.72 to 1.53) | 1.49 (1.01 to 2.19) | 0.009 | 1.20 (1.06 to 1.35) | 0.004 |
| hsCRP | |||||||
| Range, mg/L | ≤0.81 | 0.82 to 2.03 | 2.04 to 4.38 | ≥4.39 | |||
| Incidence rate per 1000 person‐years | 1.1 | 2.0 | 3.1 | 4.1 | |||
| Basic model | 1 | 1.41 (0.96 to 2.07) | 1.92 (1.33 to 2.77) | 2.02 (1.38 to 2.95) | 0.001 | 1.29 (1.14 to 1.46) | <0.0001 |
| Basic model plus lipids | 1 | 1.26 (0.85 to 1.85) | 1.61 (1.11 to 2.34) | 1.65 (1.12 to 2.43) | 0.03 | 1.22 (1.07 to 1.38) | 0.003 |
| Basic model plus lipids plus GlycA | 1 | 1.19 (0.81 to 1.75) | 1.42 (0.97 to 2.08) | 1.29 (0.85 to 1.96) | 0.58 | 1.10 (0.95 to 1.27) | 0.21 |
| Follow‐up >6 years (no. events=1226)* | |||||||
| GlycA | |||||||
| Range, μmol/L | ≤326 | 327 to 369 | 370 to 416 | ≥417 | |||
| Incidence rate per 1000 person‐years | 1.7 | 2.3 | 3.2 | 4.3 | |||
| Basic model | 1 | 1.07 (0.88 to 1.31) | 1.33 (1.11 to 1.61) | 1.48 (1.23 to 1.79) | <0.0001 | 1.22 (1.15 to 1.30) | <0.0001 |
| Basic model plus lipids | 1 | 0.95 (0.78 to 1.15) | 1.07 (0.88 to 1.29) | 1.11 (0.91 to 1.34) | 0.14 | 1.11 (1.04 to 1.19) | 0.002 |
| Basic model plus lipids plus hsCRP | 1 | 0.89 (0.73 to 1.08) | 0.95 (0.78 to 1.16) | 0.91 (0.73 to 1.12) | 0.55 | 1.04 (0.97 to 1.12) | 0.31 |
| hsCRP | |||||||
| Range, mg/L | ≤0.81 | 0.82 to 2.03 | 2.04 to 4.38 | ≥4.39 | |||
| Incidence rate per 1000 person‐years | 1.6 | 2.4 | 2.9 | 4.6 | |||
| Basic model | 1 | 1.13 (0.93 to 1.38) | 1.21 (0.99 to 1.47) | 1.69 (1.38 to 2.06) | <0.0001 | 1.27 (1.19 to 1.37) | <0.0001 |
| Basic model plus lipids | 1 | 1.02 (0.84 to 1.25) | 1.01 (0.83 to 1.24) | 1.39 (1.13 to 1.71) | <0.0001 | 1.20 (1.11 to 1.29) | <0.0001 |
| Basic model plus lipids plus GlycA | 1 | 1.00 (0.82 to 1.23) | 0.97 (0.79 to 1.20) | 1.30 (1.04 to 1.62) | 0.0006 | 1.18 (1.08 to 1.28) | 0.0002 |
Basic model for each biomarker is adjusted for age, ethnicity, smoking, systolic blood pressure, hypertensive medications, cholesterol treatment, postmenopausal status, hormone use, body mass index, diabetes, and trial treatment assignments. Lipids include low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and log triglycerides. SD is 68 μmol/L for GlycA and 5.7 mg/L for hsCRP. hsCRP indicates high‐sensitivity C‐reactive protein.
*
hsCRP was log transformed.
*
Late follow‐up, n=26 697.