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. 2014 Oct 9;3(5):e001260. doi: 10.1161/JAHA.114.001260

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 3. — Therapeutic potencies of c‐kit^DEP, CD90^DEP, and Double^DEP CDCs in a mouse model of myocardial infarction. A, Representative Masson's trichrome‐stained myocardial sections 3 weeks after treatment with control (vehicle only), unsorted CDCs, ckit^DEP CDCs, CD90^DEP CDCs, and Double^DEP CDCs. Scar tissue and viable myocardium are identified by blue and red color, respectively. B and C, Quantitative analysis of infarct thickness and viable tissue size from the Masson's trichrome images (n=5 animals per group). D and E, Left ventricular ejection fraction (LVEF) was measured by echocardiography at baseline (4 hours post‐MI) (D) and 3 weeks afterward (E). *P<0.05, when compared to control; **P<0.05, when compared to any other group. Error bars=SDs. CDCs indicates cardiosphere‐derived cells; MI, myocardial infarction.