Fig. (1).

Influenza viruses replication in upper and lower respiratory tract and neuroivasions in mice at day 3 post infection (a) and day 6 post infection (b). Groups of four mice were intranasally inoculated with 6 log10 EID50 of each virus. Lung and nasal turbinates were titrated in chicken embryos starting from 1:10 initial dilution. Brain tissues were titrated starting from 1:2 initial dilution. Virus titers were expressed as log10 EID50/mL. Brain samples in which the virus wasn't isolated were estimated as limit of detection - 0.3 log10 EID50/mL. Data are represented as means infectious titers+ SD (error bars).