Table 4.
Clinical symptoms and virus isolation from respiratory organs of ferrets after inoculation of H7N3 LAIV.
Group No. | Preparation | Ferret No | Virus dose | Clinical symptoms on dpi after inoculation | Organs sampling, dpi | Virus isolation, PFU/0.1 g (log 10) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | Lung | Nasal turbinates | |||||
1 | H7N3 LAIV | 1-3 | 106 | 0 | 0 | 0 | 0 | X | 3 | 0 | 0 |
4-6 | 106 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | ||
2 | H7N3 LAIV | 7-9 | 107 | 0 | 0 | 0 | 0 | X | 3 | 0 | 0 |
10-12 | 107 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | ||
3 | wt H7N3 | 13 | 107 | 0 | 0 | 0 | 0 | X | 3 | 0 | 1.7 |
14 | 107 | 0 | 0 | 0 | 0 | X | 5 | 1.9 | 1.9 | ||
15 | 107 | 0 | 0 | 0 | 0 | X | 3 | 0 | 3.7 | ||
16-18 | 107 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | ||
4 | LAIV H1N1 | 19-21 | 107 | 0 | 0 | 0 | 0 | X | 3 | 0 | 0 |
22-24 | 107 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 |
0 – absence of clinical symptoms, X- no data