. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2014 Dec 4;24(2):442–447. doi: 10.1158/1055-9965.EPI-14-1131

Table 1.

Chromosome regions with the most statistically significant linkage: mean tests and Haseman-Elston regression (in sibling pairs only).

Chromosome Location (cM)	Concordantly affected sibling pairs (n=27)			Discordantly affected sibling pairs (n=84)			Concordantly unaffected sibling pairs (n=19)			H-E P value^a
Chromosome Location (cM)	Allele sharing	SE	P value	Allele sharing	SE	P value	Allele sharing	SE	P value	H-E P value^a
3 (196)	0.587	0.060	0.079	0.415	0.030	0.001	0.589	0.055	0.061	0.00008^b
16 (83)	0.486	0.068	0.580	0.475	0.037	0.252	0.530	0.066	0.327	0.00010^c

Note: the three mean tests are not adjusted for any covariates. All tests are one-sided as implemented in SIBPAL.

Based on 1 million replicate permutations.

Haseman-Elston regression with W4 regression (dependent variable is a weighted combination of sibpair mean-corrected squared trait sum and sibpair squared trait difference), and adjusting for date of birth (pairwise sum and absolute difference) and African ancestry proportion (pairwise absolute difference).

Original Haseman-Elston regression (dependent variable is sibpair squared trait difference), and adjusted for date of birth (pairwise sum and absolute difference) and African ancestry proportion (pairwise absolute difference).