Table 1.
Association of clinical factors with log(IL-12p40) among 1066 patients
| Discovery set(=573) | Case validation set 1(=249) | Case validation set 2(=244) | |||||||
|---|---|---|---|---|---|---|---|---|---|
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| |||||||||
| Variable | N | Mean(SD) | P-value | N | Mean(SD) | P-value | N | Mean(SD) | P-value |
| Age at diagnosis | 573 | 53.15(15.09) | - | 249 | 52.79(13.64) | - | 244 | 46.06(14.98) | - |
|
| |||||||||
| Sex | |||||||||
| Male | 321 | 4.28(0.59) | 0.2657 | 159 | 4.47(0.58) | 0.0002 | 118 | 4.14(0.56) | 0.0079 |
| Female | 252 | 4.34(0.61) | 90 | 4.75(0.51) | 126 | 4.35(0.64) | |||
|
| |||||||||
| Stage at diagnosis | |||||||||
| I, II | 453 | 4.28(0.58) | 0.0171 | 106 | 4.55(0.56) | 0.5903 | 192 | 4.26(0.64) | 0.6467 |
| III, IV | 120 | 4.42(0.64) | 143 | 4.59(0.57) | 52 | 4.21(0.48) | |||
|
| |||||||||
| Tumor thickness | |||||||||
| 0–1 | 222 | 4.23(0.51) | 0.3046 | 68 | 4.52(0.62) | 0.7973 | 116 | 4.27(0.64) | 0.8501 |
| 1–2 | 150 | 4.33(0.64) | 51 | 4.58(0.56) | 47 | 4.27(0.66) | |||
| 2–4 | 89 | 4.33(0.61) | 66 | 4.61(0.56) | 40 | 4.19(0.52) | |||
| 4- | 53 | 4.36(0.68) | 23 | 4.53(0.53) | 23 | 4.18(0.56) | |||
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| |||||||||
| Ulceration | |||||||||
| Not present | 396 | 4.29(0.58) | 0.6541 | 155 | 4.57(0.57) | 0.5076 | 179 | 4.27(0.63) | 0.2380 |
| Present | 92 | 4.32(0.64) | 47 | 4.51(0.61) | 41 | 4.18(0.54) | |||
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| |||||||||
| Mitosis | |||||||||
| 0–1 | 124 | 4.27(0.57) | 0.7849 | 51 | 4.52(0.53) | 0.4165 | 1 | 3.58(-) | - |
| 1- | 291 | 4.29(0.60) | 141 | 4.60(0.60) | 206 | 4.26(0.62) | |||
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| |||||||||
| Sentinel lymph node | |||||||||
| Negative | 339 | 4.26(0.59) | 0.1147 | 70 | 4.53(0.59) | 0.7592 | 137 | 4.31(0.63) | 0.3331 |
| Positive | 70 | 4.38(0.63) | 67 | 4.57(0.61) | 40 | 4.20(0.50) | |||