Table 4.

Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between serum C-reactive protein concentration and risks of death from chronic liver disease in a nested case-control within the Nutrition Intervention Trials cohort

	Continuousa		Quartileb
			Q1(n=247)c		Q2 (n=260)c			Q3 (n=255)c			Q4 (n=256)c
	OR	95%CI	nd	OR (Reference)	nd	OR	95%CI	nd	OR	95%CI	nd	OR	95%CI	Ptrend	Pinteraction
Crude	1.01	1.00 to 1.02	37	1.00	56	1.44	0.92 to 2.26	69	1.81	1.17 to 2.79	114	2.97	1.97 to 4.48	<0.001	–
Age- and sex-adjusted	1.01	1.00 to 1.02	–	1.00	–	1.45	0.92 to 2.27	–	1.83	1.18 to 2.83	–	3.03	2.00 to 4.58	<0.001	–
Fully adjustede	1.01	0.99 to 1.02	–	1.00	–	1.44	0.89 to 2.31	–	1.68	1.06 to 2.67	–	2.95	1.90 to 4.57	<0.001	–
Womenf	1.00	0.98 to 1.02	18	1.00	30	1.67	0.86 to 3.26	37	2.18	1.13 to 4.23	52	3.14	1.66 to 5.96	<0.001	0.39
Meng	1.02	0.99 to 1.04	19	1.00	26	1.22	0.62 to 2.41	32	1.29	0.67 to 2.49	62	2.80	1.52 to 5.13	<0.001
Follow up yearse
<7	1.02	1.00 to 1.04	12	1.00	9	0.64	0.26 to 1.59	14	0.99	0.43 to 2.25	35	2.52	1.22 to 5.19	0.001	0.54
≥7 to <14	1.01	0.99 to 1.03	15	1.00	22	1.35	0.67 to 2.73	27	1.76	0.89 to 3.48	38	2.52	1.31 to 4.82	0.003
≥14	1.01	0.99 to 1.03	10	1.00	25	2.50	1.14 to 5.45	28	2.95	1.36 to 6.41	41	5.00	2.36 to 10.57	<0.001
HBV/HCV positivityh
HBV+	1.01	1.00 to 1.03	23	1.00	40	1.92	1.10 to 3.34	51	2.41	1.41 to 4.14	83	4.15	2.48 to 6.93	<0.001	0.17
HCV+	1.01	0.98 to 1.04	6	1.00	8	1.28	0.43 to 3.83	17	2.63	0.99 to 6.95	16	2.81	1.05 to 7.55	0.01	1.00
HBV+ or HCV +	1.01	1.00 to 1.02	24	1.00	42	1.69	0.99 to 2.87	54	2.27	1.35 to 3.81	85	3.51	2.15 to 5.74	<0.001	–
Neither	1.01	0.98 to 1.03	13	1.00	14	0.92	0.42 to 2.02	15	0.83	0.38 to 1.83	29	1.76	0.87 to 3.54	0.08	–
Trial
Dyplasia Trial	1.04	0.97 to 1.11	3	1.00	6	1.61	0.34 to 7.51	10	2.12	0.48 to 9.34	10	3.42	0.79 to 14.91	0.08	0.53
General Population Trial	1.01	0.99 to 1.02	34	1.00	50	1.42	0.86 to 2.35	59	1.63	0.99 to 2.66	104	3.00	1.89 to 4.76	<0.001

^aORs for continuous C-reactive protein were scaled to one half the interquartile range ( 0.40 mg/L).

^bWe used sex specific cut off values to calculate relative risks. Quartiles for women: <0.16, ≥0.16 to <0.37, ≥0.37 to <0.90, ≥0.90 (mg/L); Quartiles for men: <0.14, ≥0.14 to <0.32, ≥0.32 to <0.78, ≥0.78 (nmol/L).

^cNumber of subjects in the control group.

^dn cases.

^eAdjusted for age, sex, smoking, drinking, BMI, HBsAg, HBcAg and HCsAg.

^fAdjusted for age, drinking, BMI, HBsAg, HBcAg and HCsAg.

^gAdjusted for age, smoking, drinking, BMI, HBsAg, HBcAg and HCsAg.

^hAdjusted for age, sex, smoking, drinking, BMI, HBsAg/HBcAg or HCsAg.