Table 5.

Invasive Cancer versus Screen Normals

		Training		Validation
Marker	AUC	p value1	Invert2	AUC	p value
bFGF	0.769	3.1e−07	Yes	0.724	2.1e−05*
NME2	0.759	8.2e−07	Yes	0.772	2.4e−07*
GLO1	0.746	3.0e−06	Yes	0.784	6.9e−08*
hS100A6	0.733	9.4e−06	Yes	0.803	9.0e−09*
S100A4	0.709	7.0e−05	Yes	0.737	6.9e−06*
CEA	0.697	0.0002		0.583	0.117
ErbB2	0.678	0.001		0.551	0.336
MBD1	0.67	0.001	Yes	0.556	0.279
E−cadherin	0.669	0.001		0.625	0.011*
AKR1B1	0.668	0.001	Yes	0.651	0.004*
Eotaxin	0.666	0.002	Yes	0.626	0.016*
MCP−4	0.666	0.002	Yes	0.55	0.343
ICAM	0.654	0.003		0.643	0.007*
CA125	0.651	0.004		0.589	0.091
IL−1β	0.643	0.006	Yes	0.583	0.109
GSTM1	0.64	0.008	Yes	0.619	0.023
MCP−1	0.639	0.008	Yes	0.621	0.022*
TARC	0.637	0.009	Yes	0.658	0.003*
GPI	0.637	0.009	Yes	0.645	0.006*
ODC1	0.633	0.011	Yes	0.6	0.057
RAC1	0.631	0.012	Yes	0.665	0.002
IL−10	0.63	0.013		0.504	0.933
SERPINB3	0.624	0.018	Yes	0.521	0.693
Osteoprotegerin	0.622	0.02		0.537	0.483
GSTM2	0.622	0.02	Yes	0.588	0.091
TNFRI	0.619	0.024		0.583	0.114
TNFRII	0.616	0.027		0.554	0.309
VEGF−C	0.613	0.031	Yes	0.651	0.004*
LBP	0.612	0.033		0.697	0.0002
SAT	0.612	0.034	Yes	0.606	0.043
IL−12p70	0.611	0.035		0.575	0.152
VEGF	0.608	0.041	Yes	0.585	0.108
SFN	0.607	0.042	Yes	0.521	0.697
Eotaxin−3	0.604	0.049	Yes	0.626	0.016

^*Also significant for benign vs. normal

¹All markers with unadjusted p values less than 0.05 in the training phase are shown.

²If “yes”, then the values were higher in the controls compared to cases.