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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Exp Hematol. 2014 Nov 8;43(2):100–109.e1. doi: 10.1016/j.exphem.2014.10.013

Figure 2. Down-regulated expression of CXCR4 by MF splenic and PB CD34+ cells.

Figure 2

(A) A representative flow cytometric plot demonstrating the proportion of mPB, splenic and PB MF CD34+ cells expressing CXCR4 and mean fluorescence intensity (MFI) of CXCR4 on these CD34+ cells. Data of Patient E are shown. (B-C) The proportion of both splenic and PB MF CD34+ cells expressing CXCR4 (B) and the MFI of CXCR4 expression on both splenic and PB MF CD34+ cells were significantly decreased as compared with mPB CD34+ cells. N=6. mPB: G-CSF mobilized peripheral blood; MF SP: myelofibrosis spleen; MF PB: myelofibrosis peripheral blood. *, P < 0.05; **, P < 0.01; ***, P < 0.001.