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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Aug 17;1851(4):397–413. doi: 10.1016/j.bbalip.2014.08.006

Figure 2. Protectin Biosynthetic Pathway.

Figure 2

PD1 produced enzymatically from the 16S, 17S epoxy protectin (pictured in a tentative double bond geometry) was confirmed by epoxide trapping experiments. Non-enzymatic hydrolysis of this epoxide intermediate formed two minor products, the all-trans-triene isomer and vicinal 16, 17S diol.

The 10S, 17S double dioxygenation pathway and product occur by sequential actions of two lipoxygenation enzymes as demonstrated in cell incubation and isolated enzymes carried out under an enriched atmosphere of 18O2. See text for further details.