Figure 5. Postpartum mammary gland tumor growth is delayed by IL-10 depletion.
(A) Primary tumor growth of nullip and INV group mice treated with αIL-10 neutralizing antibody or rat IgG1 isotype control with treatment schedules depicted with arrows. Average tumor volume ±SEM (n=5–12mice/group), *P<0.04 vs INV IgG, ** P<0.0001 vs INV IgG. Mean frequency of CD4+ (B) and CD8+ (C) T cells are elevated in αIL-10 INV group tumors ±SEM (n=5–6mice/group), *P<0.05 vs INV IgG.